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Single-cell RNA sequencing of murine hearts to dissect immunological networks and cellular complexity in Coxsackievirus B3 induced autoimmune myocarditis
Development of a T cell receptor Transgenic Mouse Model specific to Sarcoplasmic/endoplasmic reticulum calcium ATPase 2a to study it’s role in autoimmune myocarditis
Development of a monovalent CVB3 vaccine virus that offers cross protection against CVB3 and CVB4 infections
Nano COVID-19 Vaccines for Intranasal Delivery
Published in Immunobiology, 2019
Recommended citation: Arumugam, R., Yalaka, B., Massilamany, C., Haider Ali, M., Lasrado, N., Jayaraja, S., Riethoven, J. J., Sun, X., & Reddy, J. 2020. An evidence for surface expression of an immunogenic epitope of sarcoplasmic/endoplasmic reticulum calcium-ATPase2a on antigen-presenting cells from naive mice in the mediation of autoimmune myocarditis. Immunobiology. https://www.sciencedirect.com/science/article/abs/pii/S0171298519302839
Published in Viruses, 2020
Recommended citation: Lasrado, N., Gangaplara, A., Arumugam, R., Massilamany, C., Pokal, S., Zhou, Y., Xiang, S.-H., Steffen, D., Reddy, J. 2020. Identification of Immunogenic Epitopes That Permit the Detection of Antigen-Specific T Cell Responses in Multiple Serotypes of Group B Coxsackievirus Infections. Viruses. https://www.mdpi.com/1999-4915/12/3/347.
Published in Frontiers in Cell and Developmental Biology, 2020
Recommended citation: Lasrado N, Yalaka B and Reddy J. 2020. Triggers of Inflammatory Heart Disease. Front. Cell Dev. Biol. https://doi.org/10.3389/fcell.2020.00192
Published in Reviews in Medical Virology, 2020
Recommended citation: Lasrado N, Reddy J. 2020. An overview of the immune mechanisms of viral myocarditis. Rev Med Virol. https://onlinelibrary.wiley.com/doi/10.1002/rmv.2131
Published in Molecular Immunology, 2020
Recommended citation: Basavalingappa R*, Arumugam R*, Lasrado N* , Yalaka B, Massilamany C, Gangaplara A, Xiang S, Steffen D and Reddy J. 2020. Viral myocarditis involves the generation of autoreactive T cells with multiple antigen specificities that compartmentalize in lymphoid and non-lymphoid organs in the mouse model of CVB3 infection, Molecular Immunology. *co-first authors. https://www.sciencedirect.com/science/article/abs/pii/S0161589020303953
Published in Vaccines, 2020
Recommended citation: Gangaplara, A., Massilamany, C., Lasrado, N. , Steffen, D., Reddy, J., 2020. Evidence for anti-viral effects of complete Freund’s adjuvant in the mouse model of enterovirus infection. Vaccines, 2020. https://www.mdpi.com/2076-393X/8/3/364
Published in Biology of Sex Differences, 2020
Recommended citation: Lasrado, N., Jia, T., Massilamany, C., Franco, R., Illes, Z., Reddy, J., 2020. Mechanisms of sex hormones in autoimmunity: focus on EAE. Biology of Sex Differences. https://link.springer.com/article/10.1186/s13293-020-00325-4
Published in Scientific Reports, 2021
Recommended citation: Lasrado, N., Gangaplara, A., Massilamany, C., Arumugam, R., Shelbourn, A., Rasquinha, M., Basavalingappa, R., Delhon, G., Xiang, S-H., Pattnaik, A., Steffen, D., Reddy, J., 2021. Attenuated strain of CVB3 with a mutation in the CAR-interacting region protects against both myocarditis and pancreatitis. Sci Rep. https://www.nature.com/articles/s41598-021-90434-w
Published in The Journal of Immunology, 2021
Recommended citation: Rasquinha, M.* , Sur, M.*, Lasrado, N.*, Reddy, J., 2021. IL-10 as a Th2 Cytokine: Differences Between Mice and Humans. The Journal of Immunology. * equal first authors. https://journals.aai.org/jimmunol/article/207/9/2205/234632
Published in Microorganisms, 2021
Recommended citation: Lasrado, N., Arumugam, R., Rasquinha, M., Sur, M., Steffen, D., Reddy, J., 2021. Mt10-CVB3 Vaccine Virus Protects against CVB4 Infection by Inducing Cross-Reactive, Antigen-Specific Immune Responses. Microorganisms. https://www.mdpi.com/2076-2607/9/11/2323.
Published in iScience, 2022
Recommended citation: Lasrado, N., Borcherding N, Arumugam R, Starr TK, Reddy J. 2020. Dissecting the cellular landscape and transcriptome network in viral myocarditis by single-cell RNA sequencing. iScience. https://www.cell.com/iscience/fulltext/S2589-0042(22)00135-3
Published in Biology, 2022
Recommended citation: Rasquinha, M.T.; Lasrado, N.; Petro-Turnquist, E.; Weaver, E.; Venkataraman, T.; Anderson, D.; Laserson, U.; Larman, H.B.; Reddy, J., 2022. PhIP-Seq Reveals Autoantibodies for Ubiquitously Expressed Antigens in Viral Myocarditis. Biology. https://www.mdpi.com/2079-7737/11/7/1055
Published in Cell Reports, 2022
Recommended citation: Won T, Kalinoski HM, Wood MK, Hughes DM, Jaime CM, Delgado P, Talor MV, Lasrado, N., Reddy J, Čiháková D. 2020. Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis. Cell Rep. https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01480-2
Published in Vaccines, 2022
Recommended citation: Rasquinha, M. T.* , Lasrado, N.*, Sur, M., Mone, K., Qiu, H., Riethoven, J.-J., Sobel, R. A., & Reddy, J. 2023. A Monovalent Mt10-CVB3 Vaccine Prevents CVB4-Accelerated Type 1 Diabetes in NOD Mice. Vaccines. *co-first authors. https://www.mdpi.com/2076-393X/11/1/76
Published in The New England Journal of Medicine, 2023
Recommended citation: Miller J, Hachmann NP, Collier AY, Lasrado, N, Mazurek CR, Patio RC, Powers O, Surve N, Theiler J, Korber B, Barouch DH. 2023. Substantial Neutralization Escape by SARS-CoV-2 Omicron Variants BQ.1.1 and XBB.1. N Engl J Med. https://www.nejm.org/doi/10.1056/NEJMc2214314
Published in Vaccines, 2023
Recommended citation: Mone, K.,* , Lasrado, N.*, Sur, M., & Reddy, J. 2023. Vaccines against Group B Coxsackieviruses and Their Importance. Vaccines. *co-first authors. https://www.mdpi.com/2076-393X/11/2/274
Published in The Journal of Infectious Diseases, 2023
Recommended citation: Lasrado, N., Barouch D.H. 2023. SARS-CoV-2 Hybrid Immunity: The Best of Both Worlds. The Journal of Infectious Diseases. https://academic.oup.com/jid/article/228/10/1311/7245175
Published in Cells, 2023
Recommended citation: Sur, M., Rasquinha, M. T., Arumugam, R., Massilamany, C., Gangaplara, A., Mone, K., Lasrado, N., Yalaka, B., Doiphode, A., Gurumurthy, C., Steffen, D., & Reddy, J. 2023. Transgenic Mice Expressing Functional TCRs Specific to Cardiac Myhc-α 334–352 on Both CD4 and CD8 T Cells Are Resistant to the Development of Myocarditis on C57BL/6 Genetic Background. Cells. https://www.mdpi.com/2073-4409/12/19/2346
Published in Vaccine, 2023
Recommended citation: Lasrado, N., Collier AY, Hachmann NP, Miller J, Rowe M, Schonberg ED, Rodrigues SL, LaPiana A, Patio RC, Anand T, Fisher J, Mazurek CR, Guan R, Wagh K, Theiler J, Korber BT, Barouch DH. 2023. Neutralization escape by SARS-CoV-2 Omicron subvariant BA.2.86. Vaccine. https://www.sciencedirect.com/science/article/pii/S0264410X23012537?via%3Dihub
Published in Cells, 2024
Recommended citation: Sur, M., Rasquinha, M. T., Mone, K., Massilamany, C., Lasrado, N., Gurumurthy, C., Sobel, R. A., & Reddy, J. 2024. Investigation into Cardiac Myhc-α 334–352-Specific TCR Transgenic Mice Reveals a Role for Cytotoxic CD4 T Cells in the Development of Cardiac Autoimmunity. Cells. https://www.mdpi.com/2073-4409/13/3/234
Published in Science Advances, 2024
Recommended citation: Lasrado N, Collier AY, Miller J, Hachmann NP, Liu J, Anand T, A Bondzie E, Fisher JL, Mazurek CR, Patio RC, Rodrigues SL, Rowe M, Surve N, Ty DM, Wu C, Chicz TM, Tong X, Korber B, McNamara RP, Barouch DH. 2024. Waning immunity and IgG4 responses following bivalent mRNA boosting. Sci Adv. https://www.science.org/doi/full/10.1126/sciadv.adj9945
Published in Vaccines, 2024
Recommended citation: Rasquinha, M. T., Mone, K., Sur, M., Lasrado, N., Massilamany, C., Kachman, S. D., Steffen, D., & Reddy, J. 2024. Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes. Vaccines. https://www.mdpi.com/2073-4409/13/3/234
Published in bioRxiv, 2024
Recommended citation: Turner S, Amirthalingam G, Bailey D, Barouch DH, Bewley KR, Brown K, Cao Y, Chan Y, Charlton S, DOVE consortium, Coombes NS, Hallis B, Ho DD, Jian F, Lasrado N, Lassaunière R, Liu L, Montefiori DC, Moss P, Newman J, Parry H, Polacek C, Rasmussen M, Shao F, Shen X, Thakur N, Thomson EC, Wang J, Wang P, Wang Q, Willett BJ, Yisimayi A, Smith DJ. 2024. Global variation in prior exposure shapes antibody neutralization profiles of SARS-CoV-2 variants up to BA.2.86. bioRxiv. https://doi.org/10.1101/2024.03.27.586820
Published in Vaccine, 2024
Recommended citation: Lasrado N, Rössler A, Rowe M, Collier AY, Barouch DH. 2024. Neutralization of SARS-CoV-2 Omicron subvariant BA.2.87.1. Vaccine. https://doi.org/10.1016/j.vaccine.2024.03.007
Published in Science Translational Medicine, 2024
Recommended citation: Lasrado N, Rowe M, McMahan K, Hachmann NP, Miller J, Jacob-Dolan C, Liu J, Verrette B, Gotthardt KA, Ty DM, Pereira J, Mazurek CR, Hoyt A, Collier AY, Barouch DH. 2024. SARS-CoV-2 XBB.1.5 mRNA booster vaccination elicits limited mucosal immunity. Sci Transl Med. https://www.science.org/doi/abs/10.1126/scitranslmed.adp8920
Published in Cell Reports, 2025
Recommended citation: Rössler A, Netzl A, Lasrado N, Chaudhari J, Mühlemann B, Wilks SH, Kimpel J, Smith DJ, Barouch DH. 2025. Nonhuman primate antigenic cartography of SARS-CoV-2. Cell Rep. https://www.cell.com/cell-reports/fulltext/S2211-1247(24)01491-8
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